| PowerPoint presentations, unless otherwise indicated: |
Week 1
Mon 8 Oct |
Introduction to neglected tropical diseases [pdf] - Professor Alan Fenwick |
| Eye health and health system strengthening – Dr Caroline Harper (CEO of Sightsavers) |
| Essential reading: Strengthening health systems to improve health outcomes [pdf] - WHO |
Optional reading: Eye health systems assessment (EHSA)... [pdf] |
| Tues 9 Oct |
Burden of disease [pdf] – Dr Wendy Harrison |
| Thurs 11 Oct |
Diarrhoeal disease [pdf] + diagram [pdf] - Dr Graham Cooke |
Essential reading: Diarrhoea: why children are still dying... [pdf] - Unicef, WHO |
Even more neglected tropical diseases [pdf] - Professor Alan Fenwick |
| Recommended reading: The Schistosomiasis Control Initiative (SCI) |
Waterborne infectious diseases |
Mass treatment and drug resistance [pdf] - Professor Joanne Webster |
| Recommended reading: Genetic consequences of mass human chemotherapy for schistosoma mansoni: population structure pre- and post-praziquantel treatment in Tanzania |
| The impact of single versus mixed schistosome species infections on liver, spleen and bladder morbidity within Malian children pre- and post-praziquantel treatment |
| Evolutionary concepts in predicting and evaluating the impact of mass chemotherapy schistosomiasis control programmes on parasites and their hosts |
Biological and biomedical implications of the co-evolution of pathogens and their hosts |
| School health and nutrition: Levelling the playing field – Aulo Gelli |
| Essential reading: School feeding programs... [pdf] - The World Bank Research Observer |
| Recommended reading: Rethinking school feeding - Donald Bundy, The World Bank |
| Rethinking school health - Donald Bundy, The World Bank |
| Fri 12 Oct |
Research methods: Outbreak investigation - with answers [pdf] - Dr Daniel Gibbons |
| Reading: Jardine A et al. 2011. An outbreak of Salmonella typhimurium 108/170 at a privately catered barbeque at a Sydney sports club. Foodborne Pathog Dis. 2011;8(11):1215-9 |
Health Protection Agency 2011: Salmonella – Clinical information |
| Pathogens and dirty water [pdf] - Professor Stephen Smith |
| Water, sanitation and health [pdf] - Dr Michael Templeton |
|
| Introduction to zoonotic tropical diseases [pdf] - Dr Wendy Harrison |
Essential reading: Global trends in emerging infectious diseases |
Essential reading: The control of neglected zoonotic diseases [pdf] |
Week 2
Mon 15 Oct |
The health impact of influenza and how it might be reduced [pdf] - Professor
Peter Openshaw |
| Essential reading: Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation |
Recommended reading: Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection |
Optional reading:
IFITM3 restricts the morbidity and mortality associated with influenza |
| How does surveillance and modelling help us control respiratory viruses? [pdf] - Dr Peter White |
Modelling the influenza A/H1N1 (2009) pandemic in real time [pdf] - Dr Peter White |
| Essential reading: Studies needed to address public health challenges of the 2009 H1N1 influenza pandemic -
PLoS Medicine |
Optional reading: Pandemic potential of a strain of influenza A (H1N1) |
Vaccination against pandemic influenza A/H1N1v in England |
| Tues 16 Oct |
Use of ART for prevention in Africa [pdf] - Dr Sarah Fidler |
| Recommended reading: Prevention of HIV-1 infection with early antiretroviral therapy |
Review article: HIV treatment as prevention and HPTN 052 |
| Wed 17 Oct |
Airborne pollution and global health [pdf] - Professor Majid Ezzati |
| Essential reading: Indoor air pollution and health in developing countries [pdf] - The Lancet |
Essential reading: Exposure assessment for estimation of the global burden of disease attributable to outdoor air pollution |
| Essential reading: Within-neighborhood patterns and sources of particle pollution... |
| Challenges in paediatric tuberculosis and community control [pdf] - Professor Beate Kampmann |
| Suggested reading: Paediatric tuberculosis |
| Thurs 18 Oct |
Latent TB infection and global TB control [pdf] - Professor Ajit Lalvani |
Essential reading: Redefining latent tuberculosis |
Recommended reading: Diagnosing latent tuberculosis in high-risk individuals |
Spotting latent infection: the path to better tuberculosis control |
| Border policy and TB control [pdf] - Dr Manish Pareek |
| Essential reading: Screening of immigrants in the UK for imported latent tuberculosis |
| Recommended reading: Evaluation of immigrant tuberculosis screening in industrialized countries |
| Community-based evaluation of immigrant tuberculosis screening ... |
| Tuberculosis screening of migrants to low-burden nations |
| New advances in TB vaccination [pdf] - Dr Samantha Sampson |
| Essential reading: Fact and fiction in tuberculosis vaccine research: 10 years later |
| Optional reading: Immunogenicity and protective efficacy of prime-boost regimens... |
Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys |
| Fri 19 Oct |
MDR-TB: a growing challenge to global health - case studies [pdf] + diagram [pdf] - Dr Graham Cooke and Phillip Du Cros (MSF) |
| Childhood pneumonia - the forgotten killer [pdf] - Dr Aran Singanayagam |
Week 3
Mon 22 Oct |
HIV and STIs: the tools for global control + diagram [pdf] - Dr Graham Cooke |
Recommended reading: HIV prevention transformed: the new prevention research agenda |
Prevention of HIV-1 infection with early antiretroviral therapy |
| Pre-exposure prophylaxis for HIV - where do we go from here? |
| Biomedical prevention in HIV part 1 and part 2 [pdf] - Professor Robin Shattock |
| Essential reading: The future of HIV prevention |
Recommended reading: Preventing HIV transmission through antiretroviral treatment... |
Improved outlook on HIV-1 prevention and vaccine development |
Microbicides: topical prevention against HIV |
Antiviral agents and HIV prevention: controversies, conflicts, and consensus |
| Optional reading: HIV vaccine development |
| Structural, social and behaviour barriers to the biomedical prevention of HIV transmission - Rahma Elmahdi and Tanvi Rai |
Essential reading: Structural barriers to ART adherence in Southern Africa |
Recommended reading: Meta-analysis of high-risk sexual behavior in persons aware and unaware they are infected with HIV in the United States... |
Recommendations and reality: perceived patient, provider, and policy barriers to implementing routine HIV screening and proposed solutions |
Projecting the benefits of antiretroviral therapy for HIV prevention... |
Optional reading: The effectiveness of male circumcision for HIV prevention... |
Reductions in risk behaviour provide the most consistent explanation for declining HIV-1 prevalence in Uganda |
| Tues 23 Oct |
Research methods: Case studies of STI [pdf] - Professor Helen Ward |
| Reading: Prevention strategies for sexually transmitted infections... |
Optional reading: The re-emergence of 'trafficking': sex work between slavery and freedom |
| Syphilis: what do we need to eradicate disease - Craig Tipple |
| Essential reading: Update on syphilis |
Recommended reading: The need and plan for global elimination of congenital syphilis |
Avoiding HIV and dying of syphilis |
Azithromycin resistance in Treponema pallidum |
Syphilis and HIV infection: an update |
Syphilis and social upheaval in China |
Optional reading: A road map for the global elimination of congenital syphilis |
Macrolide resistance in Treponema pallidum in the United States and Ireland |
Syphilis: still a major cause of infant mortality |
Biological basis for syphilis |
| Thurs 25 Oct |
Health worker migration [pdf] + Seminar on health worker migration [pdf] – Dr Mariam Sbaiti |
| Essential reading: How to bridge the gap in human resources for health |
Aid, restitution, and international fiscal redistribution in health care... [pdf] |
Recommended reading: The international migration of health workers... [pdf] |
HIV donor funding has both boosted and curbed the delivery of different non-HIV health services in sub-Saharan Africa |
The ‘Skills Drain’ of health Professionals from the developing world [pdf] |
An analysis of GAVI, the Global Fund and World Bank support for human resources for health in developing countries |
The World Health Report 2006 - working together for health |
| What do we need to do to prevent HBV related disease? [pdf] – Professor Mark Thursz |
| Essential reading: EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection [pdf] - Journal of Hepatology 2012 vol 57 |
| Recommended reading: Global eradication of hepatitis B - feasible or fallacy? - Nature |
| Recommended reading: Challenges and priorities in the management of HIV/HBV [pdf] |
| Health worker migration – Dr Mariam Sbait |
| Fri 26 Oct |
Overcoming the barriers to treatment of HIV in Africa [pdf]- Nathan Ford |
| Essential reading: The first decade of antiretroviral therapy in Africa |
| Towards an AIDS-free generation |
| Suggested reading: Getting HIV treatment to the most people |
| The 10-year struggle to provide antiretroviral treatment to people with HIV... |
| How to eliminate trachoma by 2020 - Antony Solomon |
| Essential reading: Trachoma [pdf] - The Lancet |
| Debate: The ethics of international randomised controlled trials - the SAPIT case - Dr Mariam Sbaiti, guest panelist: Dr Wing May Kong |
| Essential reading: Timing of initiation of antiretroviral drugs during tuberculosis therapy |
| Reference reading: Casebook on Ethical Issues in International Health Research |
Ethics in collaborative global health research networks |
Responsibilities in international research: a new look revisited |
The Nuremberg Code (1947) |
Week 4
Mon 29 Oct |
How do vaccines work? Immunology and maths [pdf] - Dr John Tregoning |
| Essential reading: Immunological mechanisms of vaccination |
| Vaccine preventable diseases 1 [pdf] - Dr Alasdair Bamford |
| Vaccine preventable diseases 2 [pdf] - Dr Alasdair Bamford |
| Reading: New decade of vaccines [pdf] The Lancet, June 2011 |
| Reading: VIMS Report: Global Vaccine Introduction [pdf] - IVAC |
| Q&As on part C BSc projects [pdf] – Dr Mariam Sbaiti, Professor Helen Ward |
| Tues 30 Oct |
What are the new approaches to vaccines? [pdf] - Dr Jamie Mann |
| Optional reading: Vaccines: past, present and future |
| Humanities in global health: focus on polio - Kelley Swain |
| Reading: On literature, science, and polio (for Jon Cogburn) |
Roth, P. Nemesis. London: Vintage, 2011 (there will be 5 copies of this in the library or students may want to purchase a copy) |
| Wed 31 Oct |
The big 3: Approaches to control HIV, TB and malaria - Dr Paul McKay |
Recommended reading: Vaccines against malaria |
Future vaccination strategies against tuberculosis: Thinking outside the box |
Is developing an HIV-1 vaccine possible? |
| Trust in vaccines [pdf] - Dr Heidi Larson (LSHTM) and Caitlin Jarrett |
Essential reading: Addressing the vaccine confidence gap |
Recommended reading: Protecting public trust in immunization |
Public health response to influenza A(H1N1) as an opportunity to build public trust |
| Thurs 1 Nov |
What are the other barriers to new vaccines [pdf] - Dr John Tregoning |
Essential reading: Accelerating introduction of new vaccines: barriers to introduction... |
| The global challenge of HPV and scaling up vaccination [pdf] - Dr Simon Beddows |
| Essential reading: Vaccines to prevent infections by oncoviruses |
Recommended reading: Human papillomavirus type distribution... |
Long term protection against cervical infection with the human papillomavirus... |
Prospects for new human papillomavirus vaccines |
| The role of vaccination in the control of flu pandemics [pdf] - Professor Neil Ferguson |
| Essential reading: Vaccines and antiviral drugs in pandemic preparedness |
Recommended reading: Strategies for mitigating an influenza pandemic |
The public’s Rresponse to the 2009 H1N1 influenza pandemic |
| Fri 2 Nov |
What are the obstacles to elimination of polio? [pdf] - Dr Tara Mangal |
| Vaccination Journal Club - Dr John Tregoning |
Essential reading: Efficacy of nine-valent pneumococcal conjugate vaccine... |
| Reading for discussion groups: |
| Repeat revaccination with 23-valent pneumococcal polysaccharide vaccine... |
| Hyporesponsiveness to re-challenge dose following pneumococcal... |
| A randomized study comparing combined pneumococcal conjugate... |
| Herd immunity and serotype replacement... [pdf] |
How do we do a clinical vaccine trial? [pdf] - Dr Alethea Cope |
Week 5
Mon 5 Nov |
Vector borne disease and an introduction to malaria – Dr Graham Cooke |
| Essential reading: Malaria: control vs elimination vs eradication - The Lancet |
Recommended reading: First results of phase 3 trial of RTS,S/AS01 malaria vaccine... |
Global malaria mortality between 1980 and 2010: a systematic analysis |
| Malaria elimination |
| Critical appraisal: RCT – Dr Graham Cooke |
| Mortality after fluid bolus in African children with severe infection (Maitland et al, 2011) [Word] |
| Mortality after fluid bolus in African children with severe infection |
| Tues 6 Nov |
Vector control strategies for malaria [pdf] + handout [pdf] - Dr John Marshall |
| Recommended reading: Ecology: A prerequisite for malaria elimination and eradication |
| Integrated vector management for malaria control |
Malaria control with transgenic mosquitoes |
| New Yorker article: The mosquito killer |
| New Yorker article on GM mosquitoes |
| Reference for GM mosquito risk assessment |
| Can we use existing tools to eliminate malaria? [pdf] - Professor Maria-Gloria Basáñez |
| Recommended reading: Reducing Plasmodium falciparum malaria transmission in Africa... |
Population biology of malaria within the mosquito... |
Modelling the impact of Artemisinin Combination Therapy and long-acting treatments... |
| Wed 7 Nov |
Leishmaniases: principles and unmet needs [pdf] - Dr Ingrid Müller |
| Recommended reading: Leishmaniasis impact and treatment access |
| Leishmaniasis worldwide and global estimates of its incidence |
Dengue virus infection and immunopathogenic disease - Dr Abigail Culshaw |
| Essential reading: Immune response to dengue virus and prospects for a vaccine |
| Recommended reading: Global spread and persistence of dengue |
Controversies in dengue pathogenesis |
| How will the control of infectious disease by improved by genomic analysis? [pdf] - Professor Christophe Fraser |
| Recommended reading: Routine use of microbial whole genome sequencing... |
| Whole-genome sequencing and social-network analysis of a tuberculosis outbreak |
| Pandemic potential of a strain of influenza A (H1N1): early findings |
| Rapid pneumococcal evolution in response to clinical interventions |
| Thurs 8 Nov |
Health systems and the barriers to ACT delivery [pdf] - Dr Bhargavi Rao |
| Malaria in the UK: where does it come from? [pdf] - Dr Déirdre Hollingsworth |
| Essential reading: Imported malaria and high risk groups: observational study... |
| Recommended reading: Assessing the future threat from vivax malaria in the United Kingdom... |
| Risk factors for severe disease in adults with falciparum malaria |
| Trends in imported childhood malaria in the UK: 1999–2003 |